Wythenshawe MP Mike Kane voted against air strikes in Syria.
The Labour MP backed his leader to oppose military action against so called ISIS, also known as Daesh, as 66 members voted with the government.
Opponents of the bombing fear the action will strengthen not weaken the extremists.
Attacks involving the RAF have now begun following the marathon debate in parliament yesterday.
Labour leader Jeremy Corbyn had argued that the case for war “does not stack up” and was supported by the majority of his MPs and shadow cabinet.
Opponents of British involvement in the bombing said it would raise the risk of attack in the UK.
Mr Corbyn said in speech: “After the despicable and horrific attacks in Paris last month, the question of whether the government’s proposal for military action in Syria strengthens – or undermines – our own national security must be at the centre of our deliberations.
“There is no doubt that the so-called Islamic state group has imposed a reign of sectarian and inhuman terror in Iraq, Syria and Libya. And there is no question that it also poses a threat to our own people.
“The issue is now whether extending UK bombing from Iraq to Syria is likely to reduce, or increase, that threat in Britain – and whether it will counter, or spread, the terror campaign Isil is waging across the Middle East.
“The answers don’t make the case for the government’s motion. On the contrary, they are a warning to step back and vote against yet another ill-fated twist in the never-ending war on terror.
“Isil is already being bombed in Syria or Iraq by the US, France, Britain, Russia and other powers.
“During more than a year of bombing Isil has expanded, as well as lost, territory. Those Isil gains include the Iraqi city of Ramadi and the Syrian city of Palmyra.
“The claim that superior British missiles will make the difference is hard to credit when the US and other states are struggling to find suitable targets. In other words, extending UK bombing is highly unlikely to work.”
But shadow foreign secretary Hilary Benn said the international community was “faced by fascists and what we know about fascists is that they must be defeated”.
Anti-war demonstrations were held in Manchester and outside Parliament as MPs debated the issue.